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Title: Peroxisome proliferator activated receptor gamma controls mature brown adipocyte inducibility through glycerol kinase
Authors: Lasar, David
Rosenwald, Matthias
Kiehlmann, Elke
Balaz, Miroslav
Tall, Bettina
Opitz, Lennart
Lidell, Martin E.
Zamboni, Nicola
Krznar, Petra
Sun, Wenfei
Varga, Lukas
Stefanicka, Patrik
Ukropec, Jozef
Nuutila, Pirjo
Virtanen, Kirsi
Amri, Ez-Zoubir
Enerbäck, Sven
Wahli, Walter
Wolfrum, Christian
Keywords: Brown Adipose Tissue
PPAR Gamma
Issue Date: 2018
Source: Lasar, D., Rosenwald, M., Kiehlmann, E., Balaz, M., Tall, B., Opitz, L., et al. (2018). Peroxisome proliferator activated receptor gamma controls mature brown adipocyte inducibility through glycerol kinase. Cell Reports, 22(3), 760-773.
Series/Report no.: Cell Reports
Abstract: Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice with inducible brown fat-specific deletions of PPARα, β/δ, and γ, respectively. We found that both PPARα and β/δδ are dispensable for brown fat function. In contrast, we could show that ablation of PPARγ in vitro and in vivo led to a reduced thermogenic capacity accompanied by a loss of inducibility by β-adrenergic signaling, as well as a shift from oxidative fatty acid metabolism to glucose utilization. We identified glycerol kinase (Gyk) as a partial mediator of PPARγ function and could show that Gyk expression correlates with brown fat thermogenic capacity in human brown fat biopsies. Thus, Gyk might constitute the link between PPARγ-mediated regulation of brown fat function and activation by β-adrenergic signaling.
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.12.067
Rights: © 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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