Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87884
Title: Utf1 contributes to intergenerational epigenetic inheritance of pluripotency
Authors: Bao, Qiuye
Morshedi, Amir
Wang, Fulu
Bhargy, Sharma
Pervushin, Konstantin
Yu, Wei-Ping
Dröge, Peter
Keywords: DRNTU::Science::Biological sciences
Primordial Germ Cells (PGCs)
Pluripotency
Issue Date: 2018
Source: Bao, Q., Morshedi, A., Wang, F., Bhargy, S., Pervushin, K., Yu, W.-P., et al. (2017). Utf1 contributes to intergenerational epigenetic inheritance of pluripotency. Scientific Reports, 7, 14612-.
Series/Report no.: Scientific Reports
Abstract: Undifferentiated embryonic cell transcription factor 1 (Utf1) is expressed in pluripotent embryonic stem cells (ESCs) and primordial germ cells (PGCs). Utf1 expression is directly controlled by pluripotency factors Oct4 and Sox2, which form a ternary complex with the Utf1 enhancer. The Utf1 protein plays a role in chromatin organization and epigenetic control of bivalent gene expression in ESCs in vitro, where it promotes effective cell differentiation during exit from pluripotency. The function of Utf1 in PGCs in vivo, however, is not known. Here, we report that proper development of Utf1 null embryos almost entirely depends on the presence of functional Utf1 alleles in the parental germline. This indicates that Utf1’s proposed epigenetic role in ESC pluripotency in vitro may be linked to intergenerational epigenetic inheritance in vivo. One component - or at least facilitator - of the relevant epigenetic mark appears to be Utf1 itself, since Utf1-driven tomato reporter and Utf1 are detected in mature germ cells. We also provide initial evidence for a reduced adult testis size in Utf1 null mice. Our findings thus point at unexpected functional links between the core ESC pluripotency factor network and epigenetic inheritance of pluripotency.
URI: https://hdl.handle.net/10356/87884
http://hdl.handle.net/10220/45565
ISSN: 2045-2322
DOI: 10.1038/s41598-017-14426-5
Rights: © 2018 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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