Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87893
Title: Pseudomonas aeruginosa psl exopolysaccharide interacts with the antimicrobial peptide LG21
Authors: Chin, Joyce Seow Fong
Sinha, Sheetal
Nalaparaju, Anjaiah
Yam, Joey Kuok Hoong
Qin, Zhiqiang
Ma, Luyan
Liang, Zhao-Xun
Lu, Lanyuan
Bhattacharjya, Surajit
Yang, Liang
Keywords: Pseudomonas Aeruginosa
Psl
Issue Date: 2017
Source: Chin, J. S. F., Sinha, S., Nalaparaju, A., Yam, J. K. H., Qin, Z., Ma, L., et al. (2017). Pseudomonas aeruginosa psl exopolysaccharide interacts with the antimicrobial peptide LG21. Water, 9(9), 681-.
Series/Report no.: Water
Abstract: Biofilm formation by opportunistic pathogens serves as one of the major causes of chronic and persistent infections. Bacterial cells in the biofilms are embedded in their self-generated protective extracellular polymeric substances (EPS), which include exopolysaccharides, large adhesin proteins and extracellular DNA. In this study, we identified an antimicrobial peptide (AMP) LG21 that is able to interact specifically with the Psl exopolysaccharide of Pseudomonas aeruginosa, thus it can be used as a diagnostic tool for P. aeruginosa biofilms. Molecular dynamics simulation analysis showed that residues numbered from 15 to 21 (WKRKRFG) in LG21 are involved in interacting with Psl. Our study indicates that host immune systems might detect and interact with microbial biofilms through AMPs. Engineering biofilm EPS-targeting AMPs might provide novel strategies for biofilm detection and treatment.
URI: https://hdl.handle.net/10356/87893
http://hdl.handle.net/10220/45574
ISSN: 2073-4441
DOI: http://dx.doi.org/10.3390/w9090681
Rights: © 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
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