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Title: Towards ultrasensitive malaria diagnosis using surface enhanced Raman spectroscopy
Authors: Chen, Keren
Yuen, Clement
Aniweh, Yaw
Preiser, Peter
Liu, Quan
Keywords: Surface Enhanced Raman Spectroscopy
Malaria Diagnosis
Issue Date: 2016
Source: Chen, K., Yuen, C., Aniweh, Y., Preiser, P., & Liu, Q. (2016). Towards ultrasensitive malaria diagnosis using surface enhanced Raman spectroscopy. Scientific Reports, 6, 20177-.
Series/Report no.: Scientific Reports
Abstract: We report two methods of surface enhanced Raman spectroscopy (SERS) for hemozoin detection in malaria infected human blood. In the first method, silver nanoparticles were synthesized separately and then mixed with lysed blood; while in the second method, silver nanoparticles were synthesized directly inside the parasites of Plasmodium falciparum. It was observed that the first method yields a smaller variation in SERS measurements and stronger correlation between the estimated contribution of hemozoin and the parasitemia level, which is preferred for the quantification of the parasitemia level. In contrast, the second method yields a higher sensitivity to a low parasitemia level thus could be more effective in the early malaria diagnosis to determine whether a given blood sample is positive.
ISSN: 2045-2322
DOI: 10.1038/srep20177
Rights: © 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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