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Title: Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
Authors: Tam, Zhi Yang
Ng, Sean Pin
Tan, Ling Qiao
Lin, Chih-Hsien
Rothenbacher, Dietrich
Klenk, Jochen
Boehm, Bernhard Otto
Goh, Kelvin Kau Kiat
Suwanchaikasem, Pipob
Tipthara, Pornpimol
Koenig, W.
Riepe, M.
Peter, R.
Geiger, H.
Ludolph, A.
Arnim, C. v.
Denkinger, M. D.
Yang, Song Yi
Nagel, G.
Weinmayr, G.
Rapp, K.
Dallmeier, D.
Steinacker, J. M.
Laszlo, R.
Becker, T.
Stingl, J.
Keywords: Diabetes Mellitus
Metabolite Profiling
Issue Date: 2017
Source: Tam, Z. Y., Ng, S. P., Tan, L. Q., Lin, C.-H., Rothenbacher, D., Klenk, J., . . . Laszlo, R. (2017). Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus. Scientific Reports, 7, 4392-. doi:10.1038/s41598-017-01735-y
Series/Report no.: Scientific Reports
Abstract: Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation. Globally, the prevalence of T2D has increased dramatically in all age groups. T2D in older adults is associated with higher mortality and reduced functional status, leading to higher rate of institutionalization. Despite the potential healthcare challenges associated with the presence of T2D in the elderly, the pathogenesis and phenotype of late-onset T2D is not well studied. Here we applied untargeted metabolite profiling of urine samples from people with and without late-onset T2D using ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS) to identify urinary biomarkers for late-onset T2D in the elderly. Statistical modeling of measurements and thorough validation of structural assignment using liquid chromatography tandem mass-spectrometry (LC-MS/MS) have led to the identification of metabolite biomarkers associated with late-onset T2D. Lower levels of phenylalanine, acetylhistidine, and cyclic adenosine monophosphate (cAMP) were found in urine samples of T2D subjects validated with commercial standards. Elevated levels of 5′-methylthioadenosine (MTA), which previously has only been implicated in animal model of diabetes, was found in urine of older people with T2D.
ISSN: 2045-2322
DOI: 10.1038/s41598-017-01735-y
Rights: © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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