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Title: Ocular fundus pulsations within the posterior rat eye : chorioscleral motion and response to elevated intraocular pressure
Authors: Augustin, Marco
Fialová, Stanislava
Fischak, Corinna
Schmetterer, Leopold
Hitzenberger, Christoph K.
Baumann, Bernhard
Keywords: DRNTU::Science::Medicine
Intraocular Pressure
Ocular Fundus Pulsations
Issue Date: 2017
Source: Augustin, M., Fialová, S., Fischak, C., Schmetterer, L., Hitzenberger, C. K., & Baumann, B. (2017). Ocular fundus pulsations within the posterior rat eye : chorioscleral motion and response to elevated intraocular pressure. Scientific Reports, 7, 8780-. doi:10.1038/s41598-017-09310-1
Series/Report no.: Scientific Reports
Abstract: A multi-functional optical coherence tomography (OCT) approach is presented to determine ocular fundus pulsations as an axial displacement between the retina and the chorioscleral complex in the albino rat eye. By combining optical coherence elastography and OCT angiography (OCTA), we measure subtle deformations in the nanometer range within the eye and simultaneously map retinal and choroidal perfusion. The conventional OCT reflectivity contrast serves as a backbone to segment the retina and to define several slabs which are subsequently used for quantitative ocular pulsation measurements as well as for a qualitative exploration of the multi-functional OCT image data. The proposed concept is applied in healthy albino rats as well as in rats under acute elevation of the intraocular pressure (IOP). The evaluation of this experiment revealed an increased pulsatility and deformation between the retinal and chorioscleral complex while increasing the IOP level from 15 mmHg to 65 mmHg. At IOP levels exceeding 65 mmHg, the pulsatility decreased significantly and retinal as well as choroidal perfusion vanished in OCTA. Furthermore, the evaluation of the multi-parametric experiment revealed a spatial correlation between fundus pulsatility and choroidal blood flow. This indicates that the assessed pulsatility may be a valuable parameter describing the choroidal perfusion.
ISSN: 2045-2322
DOI: 10.1038/s41598-017-09310-1
Rights: © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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