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Title: Skin dendritic cell and T cell activation associated with dengue shock syndrome
Authors: Duyen, Huynh Thi Le
Cerny, Daniela
Trung, Dinh The
Pang, Jassia
Velumani, Sumathy
Toh, Ying Xiu
Qui, Phan Tu
Hao, Nguyen Van
Simmons, Cameron
Haniffa, Muzlifah
Wills, Bridget
Fink, Katja
Keywords: Skin
Dengue Shock Syndrome
DRNTU::Science::Biological sciences
Issue Date: 2017
Source: Duyen, H. T. L., Cerny, D., Trung, D. T., Pang, J., Velumani, S., Toh, Y. X., . . . Fink, K. (2017). Skin dendritic cell and T cell activation associated with dengue shock syndrome. Scientific Reports, 7, 14224-. doi:10.1038/s41598-017-14640-1
Series/Report no.: Scientific Reports
Abstract: The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular organ and also an important site of immune reactions with a high density of dendritic cells (DCs), macrophages and T cells. We obtained skin biopsies and contemporaneous blood samples from patients within 24 hours of onset of dengue shock syndrome (DSS), and from healthy controls. We analyzed cell subsets by flow cytometry, and soluble mediators and antibodies by ELISA; the percentage of migratory CD1a+ dermal DCs was significantly decreased in the DSS patients, and skin CD8+ T cells were activated, but there was no accumulation of dengue-specific antibodies. Inflammatory monocytic cells were not observed infiltrating the skin of DSS cases on whole-mount histology, although CD14dim cells disappeared from blood.
ISSN: 2045-2322
DOI: 10.1038/s41598-017-14640-1
Rights: © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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