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Title: Sustained and cost effective silver substrate for surface enhanced Raman spectroscopy based biosensing
Authors: Ju, Jian
Liu, Wei
Perlaki, Clint Michael
Chen, Keren
Feng, Chunhua
Liu, Quan
Keywords: Raman Spectroscopy
DRNTU::Engineering::Chemical engineering
Issue Date: 2017
Source: Ju, J., Liu, W., Perlaki, C. M., Chen, K., Feng, C., & Liu, Q. (2017). Sustained and cost effective silver substrate for surface enhanced Raman spectroscopy based biosensing. Scientific Reports, 7, 6917-. doi:10.1038/s41598-017-07186-9
Series/Report no.: Scientific Reports
Abstract: While surface enhanced Raman spectroscopy (SERS) based biosensing has demonstrated great potential for point-of-care diagnostics in the laboratory, its application in the field is limited by the short life time of commonly used silver based SERS active substrates. In this work, we report our attempt towards SERS based field biosensing, involving the development of a novel sustained and cost-effective substrate composed of silver nanoparticles protected by small nitrogen-doped Graphene Quantum Dots, i.e. Ag NP@N-GQD, and its systematic evaluation for glucose sensing. The new substrate demonstrated significantly stronger Raman enhancement compared to pure silver nanoparticles. More importantly, the new substrate preserved SERS performance in a normal indoor environment for at least 30 days in both the wet and dry states, in contrast to only 10 days for pure silver nanoparticles. The Ag NP@N-GQD thin film in the dry state was then successfully applied as a SERS substrate for glucose detection in mouse blood samples. The new substrate was synthesized under mild experimental conditions, and the cost increase due to N-GQD was negligible. These results suggest that the Ag NP@N-GQD is a cost-effective and sustained SERS substrate, the development of which represents an important step towards SERS based field biosensing.
ISSN: 2045-2322
DOI: 10.1038/s41598-017-07186-9
Rights: © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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