“Locked in a cage”—A case of dengue virus 4 encephalitis
Ng, Deborah H. L.
Sadarangani, Sapna P.
Date of Issue2017
Lee Kong Chian School of Medicine (LKCMedicine)
Our patient with DENV-4 infection developed new acute neurological symptoms of confusion and expressive aphasia at day 6 of her acute dengue illness. CSF showed lymphocytic pleocytosis with a positive CSF dengue IgM and IgG. Testing for other pathogens in CSF was negative. She had not travelled to areas endemic for other flaviviruses. Although DENV-4 has been reported to potentially cause encephalitis, those cases were fatal, with multiorgan involvement and dengue haemorrhagic fever. [6,7] By contrast, our patient had no other features of severe dengue, such as severe plasma leakage, bleeding, or other organ impairment. This is the first known case of DENV-4 encephalitis with complete recovery.
PLOS Neglected Tropical Diseases
© 2017 Ng, Sadarangani. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.