Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88397
Title: Complementary intestinal mucosa and microbiota responses to caloric restriction
Authors: Duszka, Kalina
Ellero-Simatos, Sandrine
Ow, Ghim Siong
Defernez, Marianne
Paramalingam, Eeswari
Tett, Adrian
Ying, Shi
König, Jürgen
Narbad, Arjan
Kuznetsov, Vladimir A.
Guillou, Hervé
Wahli, Walter
Keywords: Caloric Restriction (CR)
Microbiota
DRNTU::Science::Medicine
Issue Date: 2018
Source: Duszka, K., Ellero-Simatos, S., Ow, G. S., Defernez, M., Paramalingam, E., Tett, A., . . . Wahli, W. (2018). Complementary intestinal mucosa and microbiota responses to caloric restriction. Scientific Reports, 8,11338-. doi:10.1038/s41598-018-29815-7
Series/Report no.: Scientific Reports
Abstract: The intestine is key for nutrient absorption and for interactions between the microbiota and its host. Therefore, the intestinal response to caloric restriction (CR) is thought to be more complex than that of any other organ. Submitting mice to 25% CR during 14 days induced a polarization of duodenum mucosa cell gene expression characterised by upregulation, and downregulation of the metabolic and immune/inflammatory pathways, respectively. The HNF, PPAR, STAT, and IRF families of transcription factors, particularly the Pparα and Isgf3 genes, were identified as potentially critical players in these processes. The impact of CR on metabolic genes in intestinal mucosa was mimicked by inhibition of the mTOR pathway. Furthermore, multiple duodenum and faecal metabolites were altered in CR mice. These changes were dependent on microbiota and their magnitude corresponded to microbial density. Further experiments using mice with depleted gut bacteria and CR-specific microbiota transfer showed that the gene expression polarization observed in the mucosa of CR mice is independent of the microbiota and its metabolites. The holistic interdisciplinary approach that we applied allowed us to characterize various regulatory aspects of the host and microbiota response to CR.
URI: https://hdl.handle.net/10356/88397
http://hdl.handle.net/10220/45762
DOI: http://dx.doi.org/10.1038/s41598-018-29815-7
Rights: © 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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