Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88224
Title: Development of small molecule probe for screening of bacterial resistant enzyme and their biomedical applications
Authors: Chan, Hui Ling
Keywords: DRNTU::Science::Chemistry
Issue Date: 2018
Source: Chan, H. L. (2018). Development of small molecule probe for screening of bacterial resistant enzyme and their biomedical applications. Master's thesis, Nanyang Technological University, Singapore.
Abstract: The work in this thesis has been aimed towards development of a small molecular probe for the screening of bacterial resistant enzymes. This thesis is divided into three main parts. Part I incorporates an introduction to gram positive and negative bacteria and its cell structure, β-lactam antibiotics with a brief insight into various core structure that drugs commonly consist of, β-lactamase enzyme mechanisms and the classifications, recent development in the use of small molecular probe for β-lactamase activities monitoring and imaging, as well as the current gaps and proposed work. Part II disclosed on a covalent labelling approach towards imaging AmpC β-lactamase activity on bacteria cell wall. Part III encloses the experimental data and references (Chapter III).
URI: https://hdl.handle.net/10356/88224
http://hdl.handle.net/10220/45819
DOI: 10.32657/10220/45819
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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