Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88803
Title: Super-resolution photoacoustic microscopy using a localized near-field of a plasmonic nanoaperture : a three-dimensional simulation study
Authors: Pramanik, Manojit
Park, Byullee
Lee, Hongki
Upputuri, Paul Kumar
Kim, Donghyun
Kim, Chulhong
Keywords: Biological Imaging
Nanoscale
DRNTU::Engineering::Bioengineering
Issue Date: 2018
Source: Park, B., Lee, H., Upputuri, P. K., Pramanik, M., Kim, D., & Kim, C. (2018). Super-resolution photoacoustic microscopy using a localized near-field of a plasmonic nanoaperture: a three-dimensional simulation study. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10494, 104945T-. doi:10.1117/12.2289418
Series/Report no.: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Abstract: Super-resolution microscopy has been increasingly important to delineate nanoscale biological structures or nanoparticles. With these increasing demands, several imaging modalities, including super-resolution fluorescence microscope (SRFM) and electron microscope (EM), have been developed and commercialized. These modalities achieve nanoscale resolution, however, SRFM cannot image without fluorescence, and sample preparation of EM is not suitable for biological specimens. To overcome those disadvantages, we have numerically studied the possibility of superresolution photoacoustic microscopy (SR-PAM) based on near-field localization of light. Photoacoustic (PA) signal is generally acquired based on optical absorption contrast; thus it requires no agents or pre-processing for the samples. The lateral resolution of the conventional photoacoustic microscopy is limited to ~200 nm by diffraction limit, therefore reducing the lateral resolution is a major research impetus. Our approach to breaking resolution limit is to use laser pulses of extremely small spot size as a light source. In this research, we simulated the PA signal by constructing the three dimensional SR-PAM system environment using the k-Wave toolbox. As the light source, we simulated ultrashort light pulses using geometrical nanoaperture with near-field localization of surface plasmons. Through the PA simulation, we have successfully distinguish cuboids spaced 3 nm apart. In the near future, we will develop the SR-PAM and it will contribute to biomedical and material sciences.
URI: https://hdl.handle.net/10356/88803
http://hdl.handle.net/10220/45934
DOI: 10.1117/12.2289418
Rights: © 2018 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Progress in Biomedical Optics and Imaging - Proceedings of SPIE and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers (SPIE). The published version is available at: [http://dx.doi.org/10.1117/12.2289418]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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