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|Title:||Engineering protein nanocages as carriers for biomedical applications||Authors:||Bhaskar, Sathyamoorthy
|Issue Date:||2017||Source:||Bhaskar, S., & Lim, S. (2017). Engineering protein nanocages as carriers for biomedical applications. NPG Asia Materials, 9(4), e371-. doi:10.1038/am.2016.128||Series/Report no.:||NPG Asia Materials||Abstract:||Protein nanocages have been explored as potential carriers in biomedicine. Formed by the self-assembly of protein subunits, the caged structure has three surfaces that can be engineered: the interior, the exterior and the intersubunit. Therapeutic and diagnostic molecules have been loaded in the interior of nanocages, while their external surfaces have been engineered to enhance their biocompatibility and targeting abilities. Modifications of the intersubunit interactions have been shown to modulate the self-assembly profile with implications for tuning the molecular release. We review natural and synthetic protein nanocages that have been modified using chemical and genetic engineering techniques to impart non-natural functions that are responsive to the complex cellular microenvironment of malignant cells while delivering molecular cargos with improved efficiencies and minimal toxicity.||URI:||https://hdl.handle.net/10356/88860
|DOI:||10.1038/am.2016.128||Rights:||© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SCBE Journal Articles|
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