dc.contributor.authorLi, Bao-Sheng
dc.contributor.authorWang, Yuhuang
dc.contributor.authorJin, Zhichao
dc.contributor.authorZheng, Pengcheng
dc.contributor.authorGanguly, Rakesh
dc.contributor.authorChi, Robin Yonggui
dc.date.accessioned2018-09-27T04:32:45Z
dc.date.available2018-09-27T04:32:45Z
dc.date.issued2015
dc.identifier.citationLi, B.-S., Wang, Y., Jin, Z., Zheng, P., Ganguly, R., & Chi, Y. R. (2015). Carbon–carbon bond activation of cyclobutenones enabled by the addition of chiral organocatalyst to ketone. Nature Communications, 6, 6207-. doi:10.1038/ncomms7207en_US
dc.identifier.urihttp://hdl.handle.net/10220/46119
dc.description.abstractThe activation of carbon–carbon (C–C) bonds is an effective strategy in building functional molecules. The C–C bond activation is typically accomplished via metal catalysis, with which high levels of enantioselectivity are difficult to achieve due to high reactivity of metal catalysts and the metal-bound intermediates. It remains largely unexplored to use organocatalysis for C–C bond activation. Here we describe an organocatalytic activation of C–C bonds through the addition of an NHC to a ketone moiety that initiates a C–C single bond cleavage as a key step to generate an NHC-bound intermediate for chemo- and stereo-selective reactions. This reaction constitutes an asymmetric functionalization of cyclobutenones using organocatalysts via a C–C bond activation process. Structurally diverse and multicyclic compounds could be obtained with high optical purities via an atom and redox economic process.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipEDB (Economic Devt. Board, S’pore)en_US
dc.format.extent5 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesNature Communicationsen_US
dc.rights© 2015 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
dc.subjectChemical Bondingen_US
dc.subjectOrganic Chemistryen_US
dc.subjectDRNTU::Science::Chemistryen_US
dc.titleCarbon–carbon bond activation of cyclobutenones enabled by the addition of chiral organocatalyst to ketoneen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1038/ncomms7207
dc.description.versionPublished versionen_US


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