Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89449
Title: Electrospun 3D fibrous scaffolds for chronic wound repair
Authors: Chen, Huizhi
Peng, Yan
Wu, Shucheng
Tan, Lay Poh
Keywords: Electrospinning
Tissue Engineering;
DRNTU::Engineering::Materials
Issue Date: 2016
Source: Chen, H., Peng, Y., Wu, S., & Tan, L. P. (2016). Electrospun 3D fibrous scaffolds for chronic wound repair. Materials, 9(4), 272-. doi:10.3390/ma9040272
Series/Report no.: Materials
Abstract: Chronic wounds are difficult to heal spontaneously largely due to the corrupted extracellular matrix (ECM) where cell ingrowth is obstructed. Thus, the objective of this study was to develop a three-dimensional (3D) biodegradable scaffold mimicking native ECM to replace the missing or dysfunctional ECM, which may be an essential strategy for wound healing. The 3D fibrous scaffolds of poly(lactic acid-co-glycolic acid) (PLGA) were successfully fabricated by liquid-collecting electrospinning, with 5~20 µm interconnected pores. Surface modification with the native ECM component aims at providing biological recognition for cell growth. Human dermal fibroblasts (HDFs) successfully infiltrated into scaffolds at a depth of ~1400 µm after seven days of culturing, and showed significant progressive proliferation on scaffolds immobilized with collagen type I. In vivo models showed that chronic wounds treated with scaffolds had a faster healing rate. These results indicate that the 3D fibrous scaffolds may be a potential wound dressing for chronic wound repair.
URI: https://hdl.handle.net/10356/89449
http://hdl.handle.net/10220/46259
ISSN: 1996-1944
DOI: http://dx.doi.org/10.3390/ma9040272
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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