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Title: Triggered release from thermoresponsive polymersomes with superparamagnetic membranes
Authors: Bixner, Oliver
Kurzhals, Steffen
Virk, Mudassar
Reimhult, Erik
Keywords: DRNTU::Engineering::Materials
Superparamagnetic Iron Oxide Nanoparticle
Thermoresponsive Polymer
Issue Date: 2016
Source: Bixner, O., Kurzhals, S., Virk, M., & Reimhult, E. (2016). Triggered release from thermoresponsive polymersomes with superparamagnetic membranes. Materials, 9(1), 29-. doi:10.3390/ma9010029
Series/Report no.: Materials
Abstract: Magnetic polymersomes were prepared by self-assembly of the amphiphilic block copolymer poly(isoprene-b-N-isopropylacrylamide) with monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPION). The specifically designed thermoresponsive block copolymer allowed for efficient incorporation of the hydrophobic nanoparticles in the membrane core and encapsulation of the water soluble dye calcein in the lumen of the vesicles. Magnetic heating of the embedded SPIONs led to increased bilayer permeability through dehydration of the thermoresponsive PNIPAM block. The entrapped calcein could therefore be released in controlled doses solely through exposure to pulses of an alternating magnetic field. This hybrid SPION-polymersome system demonstrates a possible direction for release applications that merges rational polymersome design with addressed external magnetic field-triggered release through embedded nanomaterials.
ISSN: 1996-1944
DOI: 10.3390/ma9010029
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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