Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89729
Title: Rational design of materials interface for efficient capture of circulating tumor cells
Authors: Chandran, Bevita Kallupalathinkal
Li, Yong-Qiang
Lim, Chwee Teck
Chen, Xiaodong
Keywords: Circulating Tumor Cells
Material Interface
DRNTU::Engineering::Materials
Issue Date: 2015
Source: Li, Y.-Q., Chandran, B. K., Lim, C. T., & Chen, X. (2015). Rational design of materials interface for efficient capture of circulating tumor cells. Advanced Science, 2(11), 1500118-. doi:10.1002/advs.201500118
Series/Report no.: Advanced Science
Abstract: Originating from primary tumors and penetrating into blood circulation, circulating tumor cells (CTCs) play a vital role in understanding the biology of metastasis and have great potential for early cancer diagnosis, prognosis and personalized therapy. By exploiting the specific biophysical and biochemical properties of CTCs, various material interfaces have been developed for the capture and detection of CTCs from blood. However, due to the extremely low number of CTCs in peripheral blood, there exists a need to improve the efficiency and specificity of the CTC capture and detection. In this regard, a critical review of the numerous reports of advanced platforms for highly efficient and selective capture of CTCs, which have been spurred by recent advances in nanotechnology and microfabrication, is essential. This review gives an overview of unique biophysical and biochemical properties of CTCs, followed by a summary of the key material interfaces recently developed for improved CTC capture and detection, with focus on the use of microfluidics, nanostructured substrates, and miniaturized nuclear magnetic resonance‐based systems. Challenges and future perspectives in the design of material interfaces for capture and detection of CTCs in clinical applications are also discussed.
URI: https://hdl.handle.net/10356/89729
http://hdl.handle.net/10220/46338
DOI: 10.1002/advs.201500118
Schools: School of Materials Science & Engineering 
Rights: © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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