Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89991
Title: Integrated analysis of the Plasmodium species transcriptome
Authors: Hoo, Regina
Zhu, Lei
Amaladoss, Anburaj
Mok, Sachel
Natalang, Onguma
Lapp, Stacey A.
Hu, Guangan
Liew, Kingsley
Galinski, Mary R.
Bozdech, Zbynek
Preiser, Peter Rainer
Keywords: DRNTU::Science::Biological sciences
Comparative Transcriptomics
Plasmodium Species
Issue Date: 2016
Source: Hoo, R., Zhu, L., Amaladoss, A., Mok, S., Natalang, O., Lapp, S. A., . . . Preiser, P. R. (2016). Integrated analysis of the Plasmodium species transcriptome. EBioMedicine, 7(1), 255-266. doi:10.1016/j.ebiom.2016.04.011
Series/Report no.: EBioMedicine
Abstract: The genome sequence available for different Plasmodium species is a valuable resource for understanding malaria parasite biology. However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. Here, we developed a comprehensive approach to measure transcriptional changes of the evolutionary conserved syntenic orthologs during the intraerythrocytic developmental cycle across six Plasmodium species. We show significant transcriptional constraint at the mid-developmental stage of Plasmodium species while the earliest stages of parasite development display the greatest transcriptional variation associated with critical functional processes. Modeling of the evolutionary relationship based on changes in transcriptional profile reveal a phylogeny pattern of the Plasmodium species that strictly follows its mammalian hosts. In addition, the work shows that transcriptional conserved orthologs represent potential future targets for anti-malaria intervention as they would be expected to carry out key essential functions within the parasites. This work provides an integrated analysis of orthologous transcriptome, which aims to provide insights into the Plasmodium evolution thereby establishing a framework to explore complex pathways and drug discovery in Plasmodium species with broad host range.
URI: https://hdl.handle.net/10356/89991
http://hdl.handle.net/10220/46472
DOI: 10.1016/j.ebiom.2016.04.011
Rights: © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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