dc.contributor.authorKu, Chee Wai
dc.contributor.authorTan, Zhen Wei
dc.contributor.authorLim, Mark Kit
dc.contributor.authorTam, Zhi Yang
dc.contributor.authorLin, Chih-Hsien
dc.contributor.authorNg, Sean Pin
dc.contributor.authorAllen, John Carson
dc.contributor.authorLek, Sze Min
dc.contributor.authorTan, Thiam Chye
dc.contributor.authorTan, Nguan Soon
dc.identifier.citationKu, C. W., Tan, Z. W., Lim, M. K., Tam, Z. Y., Lin, C.-H., Ng, S. P., . . . Tan, N. S. (2017). Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile. BBA Clinical, 8, 48-55. doi:10.1016/j.bbacli.2017.07.003en_US
dc.description.abstractThreatened miscarriage is the most common gynecological emergency, occurring in about 20% of pregnant women. Approximately one in four of these patients go on to have spontaneous miscarriage and the etiology of miscarriage still remains elusive. In a bid to identify possible biomarkers and novel treatment targets, many studies have been undertaken to elucidate the pathways that lead to a miscarriage. Luteal phase deficiency has been shown to contribute to miscarriages, and the measurement of serum progesterone as a prognostic marker and the prescription of progesterone supplementation has been proposed as possible diagnostic and treatment methods. However, luteal phase deficiency only accounts for 35% of miscarriages. In order to understand the other causes of spontaneous miscarriage and possible novel urine biomarkers for miscarriage, we looked at the changes in urinary metabolites in women with threatened miscarriage. To this end, we performed a case-control study of eighty patients who presented with threatened miscarriage between 6 and 10 weeks gestation. Urine metabolomics analyses of forty patients with spontaneous miscarriages and forty patients with ongoing pregnancies at 16 weeks gestation point to an impaired placental mitochondrial β-oxidation of fatty acids as the possible cause of spontaneous miscarriage. This study also highlighted the potential of urine metabolites as a non-invasive screening tool for the risk stratification of women presenting with threatened miscarriage.en_US
dc.description.sponsorshipMOH (Min. of Health, S’pore)en_US
dc.format.extent8 p.en_US
dc.relation.ispartofseriesBBA Clinicalen_US
dc.rights© 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectMass Spectrometryen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleSpontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profileen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.versionPublished versionen_US

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