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Title: Recent progresses in phototherapy-synergized cancer immunotherapy
Authors: Li, Jingchao
Pu, Kanyi
Ng, Chee Wee
Keywords: Phototherapy
DRNTU::Engineering::Chemical engineering::Biochemical engineering
Issue Date: 2018
Source: Ng, C. W., Li, J., & Pu, K. (2018). Recent progresses in phototherapy-synergized cancer immunotherapy. Advanced Functional Materials, 28(46), 1804688-. doi:10.1002/adfm.201804688
Series/Report no.: Advanced Functional Materials
Abstract: Cancer immunotherapy have recently gained much attention in the search of cancer cure due to its ability to “train” the immune system in seeking out and removing residual tumor cells. However, relying on cancer immunotherapy alone may fail to ablate primary tumors. Phototherapy is a promising modality that offers an elegant solution to eradicate tumors through the simple application of light irradiation and meanwhile triggers immune responses by immunogenic cell death to enhance antitumor immunity. Uniting phototherapy with cancer immunotherapy have been found to achieved synergistic outcomes, promote cancer regression and even attain immunologic memory. This review summarizes the recent studies on utilizing phototherapy and immunotherapy combinatorial approach to treat cancer. A variety of nanoplatforms have been investigated in combination with immunoadjuvants and immune checkpoint blockades such as CTLA4 and PD-L1 pathways. Higher levels of proinflammatory cytokines, improved migration of dendritic cells and an increased ratio of tumor-infiltrating cytotoxic T cells against regulatory T cells are revealed in many studies, offering a glimpse into the mechanistic principles. Future advancements targeting different cancer checkpoints that could offer better immunosuppression coupled with other phototherapeutic strategies remains to be explored in accomplishing complete elimination of cancer.
ISSN: 1616-301X
Rights: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Functional Materials, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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