Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87627
Title: The reproductive toxicity of CdSe/ZnS quantum dots on the in vivo ovarian function and in vitro fertilization
Authors: Xu, Gaixia
Lin, Guimiao
Lin, Suxia
Wu, Na
Deng, Yueyue
Feng, Gang
Chen, Qiang
Qu, Junle
Chen, Danni
Chen, Siping
Niu, Hanben
Mei, Shujiang
Yong, Ken-Tye
Wang, Xiaomei
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Quantum Dots
Fertilization in Vitro
Issue Date: 2016
Source: Xu, G., Lin, G., Lin, S., Wu, N., Deng, Y., Feng, G., . . . Wang, X. (2016). The Reproductive Toxicity of CdSe/ZnS Quantum Dots on the in vivo Ovarian Function and in vitro Fertilization. Scientific Reports, 6, 37677-. doi:10.1038/srep37677
Series/Report no.: Scientific Reports
Abstract: Despite the usefulness of quantum dots (QDs) in biomedicine and optoelectronics, their toxicity risks remain a major obstacle for clinical usages. Hence, we studied the reproductive toxicity of CdSe/ZnS QDs on two aspects, (i) in vivo ovarian functions and (ii) in vitro fertilization process. The body weight, estrous cycles, biodistribution of QDs, and oocyte maturation are evaluated on female mice treated with QDs. The mRNA level of the follicle-stimulating hormone receptor (FSHr) and luteinizing hormone receptor (LHr) in ovaries are assayed. Then, the matured cumulus-oocyte-complexes are harvested to co-culture with in vitro capacitated sperms, and the in vitro fertilization is performed. The result revealed that QDs are found in the ovaries, but no changes are detected on the behavior and estrous cycle on the female mice. The mRNA downregulations of FSHr and LHr are observed and the number of matured oocytes has shown a significant decrease when the QDs dosage was above 1.0 pmol/day. Additionally, we found the presence of QDs has reduced the in vitro fertilization success rate. This study highly suggests that the exposure of CdSe/ZnS QDs to female mice can cause adverse effects to the ovary functions and such QDs may have limited applications in clinical usage.
URI: https://hdl.handle.net/10356/87627
http://hdl.handle.net/10220/46759
DOI: http://dx.doi.org/10.1038/srep37677
Rights: © 2016 The Authors (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

Google ScholarTM

Check

Altmetric

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.