Please use this identifier to cite or link to this item:
|Title:||Neutralizing antibodies against plasmodium falciparum associated with successful cure after drug therapy||Authors:||Goh, Yun Shan
Chia, Wan Ni
White, Nicholas J.
|Issue Date:||2016||Source:||Goh, Y. S., Peng, K., Chia, W. N., Siau, A., Chotivanich, K., Gruner, A.-C., . . . Renia, L. (2016). Neutralizing antibodies against plasmodium falciparum associated with successful cure after drug therapy. PLOS ONE, 11(7), e0159347-. doi:10.1371/journal.pone.0159347||Series/Report no.:||PLOS ONE||Abstract:||An effective antibody response can assist drug treatment to contribute to better parasite clearance in malaria patients. To examine this, sera were obtained from two groups of adult patients with acute falciparum malaria, prior to drug treatment: patients who (1) have subsequent recrudescent infection, or (2) were cured by Day 28 following treatment. Using a Plasmodium falciparum antigen library, we examined the antibody specificities in these sera. While the antibody repertoire of both sera groups was extremely broad and varied, there was a differential antibody profile between the two groups of sera. The proportion of cured patients with antibodies against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 was higher than the proportion of patients with recrudescent infection. The presence of these antibodies was associated with higher odds of treatment cure. Sera containing all six antibodies impaired the invasion of P. falciparum clinical isolates into erythrocytes. These results suggest that antibodies specific against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 in P. falciparum infections could assist anti-malarial drug treatment and contribute to the resolution of the malarial infection.||URI:||https://hdl.handle.net/10356/87594
|DOI:||http://dx.doi.org/10.1371/journal.pone.0159347||Rights:||© 2016 Goh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.||metadata.item.grantfulltext:||open||metadata.item.fulltext:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
Files in This Item:
|Neutralizing Antibodies against Plasmodium falciparum Associated with Successful Cure after Drug Therapy.pdf||359.69 kB||Adobe PDF|
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.