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Title: Tissue-resident CD169 + macrophages form a crucial front line against plasmodium infection
Authors: Gupta, Pravesh
Lai, Si Min
Sheng, Jianpeng
Tetlak, Piotr
Balachander, Akhila
Claser, Carla
Renia, Laurent
Karjalainen, Klaus
Ruedl, Christiane
Keywords: Macrophages
Plasmodium Berghei Infection
DRNTU::Science::Biological sciences
Issue Date: 2016
Source: Gupta, P., Lai, S. M., Sheng, J., Tetlak, P., Balachander, A., Claser, C., . . . Ruedl, C. (2016). Tissue-resident CD169 + macrophages form a crucial front line against plasmodium infection. Cell Reports, 16(6), 1749-1761. doi:10.1016/j.celrep.2016.07.010
Series/Report no.: Cell Reports
Abstract: Tissue macrophages exhibit diverse functions, ranging from the maintenance of tissue homeostasis, including clearance of senescent erythrocytes and cell debris, to modulation of inflammation and immunity. Their contribution to the control of blood-stage malaria remains unclear. Here, we show that in the absence of tissue-resident CD169+ macrophages, Plasmodium berghei ANKA (PbA) infection results in significantly increased parasite sequestration, leading to vascular occlusion and leakage and augmented tissue deposition of the malarial pigment hemozoin. This leads to widespread tissue damage culminating in multiple organ inflammation. Thus, the capacity of CD169+ macrophages to contain the parasite burden and its sequestration into different tissues and to limit infection-induced inflammation is crucial to mitigating Plasmodium infection and pathogenesis.
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2016.07.010
Rights: © 2016 The Author(s). This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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