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Title: Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise
Authors: Ding, Cherlyn
Chan, Zhiling
Lo, Jezebel
Choo, John
Magkos, Faidon
Chooi, Yu Chung
Ding, Benjamin T. K.
Leow, Melvin Khee-Shing
Keywords: Lipoproteins
Issue Date: 2018
Source: Chooi, Y. C., Ding, C., Chan, Z., Lo, J., Choo, J., Ding, B. T. K., . . . Magkos, F. (2018). Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise. Nutrients, 10(11), 1814-. doi: 10.3390/nu10111814
Series/Report no.: Nutrients
Abstract: Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We determined the effects of progressive, acute energy deficits (20% or 40% of daily energy requirements) induced by a single day of calorie restriction (n = 19) or aerobic exercise (n = 13) in healthy subjects (age: 26 ± 9 years; body mass index (BMI): 21.8 ± 2.9 kg/m2). Fasting plasma concentrations of very low-, intermediate-, low-, and high-density lipoprotein (VLDL, LDL, IDL, and HDL, respectively) particles and their subclasses were determined using nuclear magnetic resonance. Total plasma triglyceride and VLDL-triglyceride concentrations decreased after calorie restriction and exercise (all p ≤ 0.025); the pattern of change was linear with an increasing energy deficit (all p < 0.03), with no evidence of plateauing. The number of circulating large and medium VLDL particles decreased after diet and exercise (all p < 0.015), with no change in small VLDL particles. The concentrations of IDL, LDL, and HDL particles, their relative distributions, and the particle sizes were not altered. Our data indicate that an acute negative energy balance induced by calorie restriction and aerobic exercise reduces triglyceride concentrations in a dose-dependent manner, by decreasing circulating large and medium VLDL particles.
ISSN: 2072-6643
Rights: © 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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