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Title: Melanogenesis Inhibitors
Authors: Kumari, Sulekha
Thng, Steven Tien Guan
Verma, Navin Kumar
Gautam, Hemant K.
Keywords: Skin Pigmentation
Issue Date: 2018
Source: Kumari, S., Thng, S. T. G., Verma, N. K., & Gautam, H. K. (2018). Melanogenesis Inhibitors. Acta Dermato Venereologica, 98(10), 924-931. doi: 10.2340/00015555-3002
Series/Report no.: Acta Dermato Venereologica
Abstract: Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These hyperpigmentary skin disorders can significantly impact an individual’s appearance, and may cause emotional and psychological distress and reduced quality of life. A large number of melanogenesis inhibitors have been developed, but most have unwanted side-effects. Further research is needed to better understand the mechanisms of hyperpigmentary skin disorders and to develop potent and safe inhibitors of melanogenesis. This review summarizes the current understanding of melanogenesis regulatory pathways, the potential involvement of the immune system, various drugs in current use, and emerging treatment strategies to suppress melanogenesis.
ISSN: 0001-5555
DOI: 10.2340/00015555-3002
Rights: © 2018 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license. Journal Compilation
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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