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Title: A critical period for antidepressant-induced acceleration of neuronal maturation in adult dentate gyrus
Authors: Åmellem, Ingrid
Suresh, S.
Chang, Ching Ching
Tok, S. S. L.
Tashiro, Ayumu
Keywords: Doublecortin
DRNTU::Science::Biological sciences
Issue Date: 2017
Source: Åmellem, I., Suresh, S., Chang, C. C., Tok, S. S. L., & Tashiro, A. (2017). A critical period for antidepressant-induced acceleration of neuronal maturation in adult dentate gyrus. Translational Psychiatry, 7(9), e1235-. doi:10.1038/tp.2017.208
Series/Report no.: Translational Psychiatry
Abstract: Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used medications for mood and anxiety disorders, and adult neurogenesis in the dentate gyrus has been shown to be involved in the behavioral effects of SSRIs in mice. Studies have shown the varied effects of chronic treatment with SSRIs on adult neurogenesis. One such effect is the acceleration of neuronal maturation, which affects the functional integration of new neurons into existing neuronal circuitry. In this study, we labeled new neurons by using GFP-expressing retroviral vectors in mice and investigated the effect of an SSRI, fluoxetine, on these neurons at different time points after neuronal birth. Chronic treatment with fluoxetine accelerated the dendritic development of the newborn neurons and shifted the timing of the expression of the maturational marker proteins, doublecortin and calbindin. This accelerated maturation was observed even after sub-chronic treatment, only when fluoxetine was administered during the second week of neuronal birth. These results suggest the existence of a ‘critical period’ for the fluoxetine-induced maturation of new neurons. We propose that the modified functional integration of new neurons in the critical period may underlie the behavioral effects of fluoxetine by regulating anxiety-related decision-making processes.
Rights: © 2017 The Author(s). This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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