Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/102601
Title: 3D/4D multiscale imaging in acute lymphoblastic leukemia cells-visualizing dynamics of cell death
Authors: Sarangapani, Sreelatha
Mohan, Rosmin Elsa
Patil, Ajeetkumar
Lang, Matthew J.
Asundi, Anand
Keywords: DRNTU::Engineering::Mechanical engineering
Cancer Cells
Chitosan
Issue Date: 2017
Source: Sarangapani, S., Mohan, R. E., Patil, A., Lang, M. J., & Asundi, A. (2017). 3D/4D multiscale imaging in acute lymphoblastic leukemia cells-visualizing dynamics of cell death. Fifth International Conference on Optical and Photonics Engineering, 10449, 1044936-. doi:10.1117/12.2270979
Abstract: Quantitative phase detection is a new methodology that provides quantitative information on cellular morphology to monitor the cell status, drug response and toxicity. In this paper the morphological changes in acute leukemia cells treated with chitosan were detected using d’Bioimager a robust imaging system. Quantitative phase image of the cells was obtained with numerical analysis. Results show that the average area and optical volume of the chitosan treated cells is significantly reduced when compared with the control cells, which reveals the effect of chitosan on the cancer cells. From the results it can be attributed that d’Bioimager can be used as a non-invasive imaging alternative to measure the morphological changes of the living cells in real time.
URI: https://hdl.handle.net/10356/102601
http://hdl.handle.net/10220/47252
DOI: http://dx.doi.org/10.1117/12.2270979
Rights: © 2017 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Fifth International Conference on Optical and Photonics Engineering and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers (SPIE). The published version is available at: [http://dx.doi.org/10.1117/12.2270979]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Conference Papers

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