Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103328
Title: Imaging cellular structures of atherosclerotic coronary arteries using circumferentially scanning micro-optical coherence tomography fiber probe ex vivo
Authors: Luo, Yuemei
Bo, En
Liang, Haitao
Wang, Xianghong
Yu, Xiaojun
Cui, Dongyao
Ge, Xin
Mo, Jianhua
Liu, Linbo
Keywords: Optical Fiber Devices
Optical Coherence Tomography
DRNTU::Engineering::Bioengineering
Issue Date: 2018
Source: Luo, Y., Bo, E., Liang, H., Wang, X., Yu, X., Cui, D., . . . Liu, L. (2018). Imaging cellular structures of atherosclerotic coronary arteries using circumferentially scanning micro-optical coherence tomography fiber probe ex vivo. IEEE Access, 6, 62988-62994. doi:10.1109/ACCESS.2018.2876919
Series/Report no.: IEEE Access
Abstract: Development and progression of coronary atherosclerotic lesions is mediated by a number of cellular components that are not readily visualized using the current clinical investigation tools. Visualizing these cellular components in situ and in vivo may allow early detection of the vulnerable plaques, with implications for coronary artery disease therapy and for the prevention of acute myocardial infarction. In this paper, we have developed a fiber-optic micro-optical coherence tomography ( μ OCT) probe for intravascular use. We conducted ex vivo imaging experiments in normal swine aorta and human atherosclerotic coronary arteries and demonstrated that the fiber-probe-based μ OCT could delineate not only the layered structures of arterial wall but also the cellular-level anatomical structures of atherosclerotic plaques, including foam cells and smooth muscle cells. These results demonstrate the feasibility of intravascular μ OCT imaging.
URI: https://hdl.handle.net/10356/103328
http://hdl.handle.net/10220/47277
DOI: 10.1109/ACCESS.2018.2876919
Rights: © 2018 IEEE. Translations and content mining are permitted for academic research only. Personal use is also permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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