dc.contributor.authorLai, Si Min
dc.contributor.authorSheng, Jianpeng
dc.contributor.authorGupta, Pravesh
dc.contributor.authorRenia, Laurent
dc.contributor.authorDuan, Kaibo
dc.contributor.authorZolezzi, Francesca
dc.contributor.authorKarjalainen, Klaus
dc.contributor.authorNewell, Evan W.
dc.contributor.authorRuedl, Christiane
dc.date.accessioned2019-01-03T08:49:52Z
dc.date.available2019-01-03T08:49:52Z
dc.date.issued2018
dc.identifier.citationLai, S. M., Sheng, J., Gupta, P., Renia, L., Duan, K., Zolezzi, F., . . . Ruedl, C. (2018). Organ-specific fate, recruitment, and refilling dynamics of tissue-resident macrophages during blood-stage Malaria. Cell Reports, 25(11), 3099-3109. doi:10.1016/j.celrep.2018.11.059en_US
dc.identifier.issn2211-1247en_US
dc.identifier.urihttp://hdl.handle.net/10220/47350
dc.description.abstractInflammation-induced disappearance of tissue-resident macrophages represents a key pathogen defense mechanism. Using a model of systemic blood-stage malaria, we studied the dynamics of tissue-resident macrophages in multiple organs to determine how they are depleted and refilled during the course of disease. We show that Plasmodium infection results in a transient loss of embryonically established resident macrophages prior to the parasitemia peak. Fate-mapping analysis reveals that inflammatory monocytes contribute to the repopulation of the emptied niches of splenic red pulp macrophages and hepatic Kupffer cells, while lung alveolar macrophages refill their niche predominantly through self-renewal. Interestingly, the local microenvironment of the spleen and liver can “imprint” the molecular characteristics of fetal-derived macrophages on newly differentiated bone marrow-derived immigrants with remarkably similar gene expression profiles and turnover kinetics. Thus, the mononuclear phagocytic system has developed distinct but effective tissue-specific strategies to replenish emptied niches to guarantee the functional integrity of the system.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent21 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesCell Reportsen_US
dc.rights© 2018 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectTissue-resident Macrophagesen_US
dc.subjectKupffer Cellsen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleOrgan-specific fate, recruitment, and refilling dynamics of tissue-resident macrophages during blood-stage Malariaen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.celrep.2018.11.059
dc.description.versionPublished versionen_US


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