dc.contributor.authorJain, Abhishek
dc.contributor.authorLi, Xin Hui
dc.contributor.authorChen, Wei Ning
dc.date.accessioned2019-01-07T06:52:10Z
dc.date.available2019-01-07T06:52:10Z
dc.date.issued2018
dc.identifier.citationJain, A., Li, X. H., & Chen, W. N. (2018). Similarities and differences in gut microbiome composition correlate with dietary patterns of Indian and Chinese adults. AMB Express, 8(1), 104-. doi:10.1186/s13568-018-0632-1en_US
dc.identifier.urihttp://hdl.handle.net/10220/47404
dc.description.abstractThe interaction between diet and gut microbiota, and ultimately their link to health, has turned into the concentration of huge research. However, this relationship still needs to be fully characterized, particularly in case of the Asian population. We compared the fecal bacterial diversity and composition of healthy Indian and Chinese adults, ages 22–35 years, using next-generation sequencing analysis on IlluminaHiSeq 2500 platform. Our analysis revealed unique community structure, dominant Firmicutes, Actinobacteria and underrepresented Bacteroides, of Indian and Chinese gut bacteria. This community structure closely matched with the gut bacterial composition of the Russian population. Therefore, we hypothesized that enrichment of these bacterial clades is supported by high consumption of starch-rich diet such as rice, potato, refined grains. The dominance of genus Bifidobacterium due to carbohydrate-rich diet is another notable feature of this study. Moreover, Indian gut bacteria are significantly represented by Bacteroidetes (p = 0.001) and Prevotella (p = 0.002) in contrast to Chinese, which could be associated with whole grains and plant-based vegetarian diet of Indians. The gut bacterial population of Indian adults were as diverse as Chinese adults (p > 0.1), but significant difference was noticed in gut bacterial composition and relative abundance between two populations (R = 0.625, p < 0.005). Partial least squares discriminant analysis and non-metric multidimensional scaling plots showed dietary habit wise clustering of subjects. Thus, the present work confirms an important role of diet in determining gut bacterial composition. LEfse analysis revealed genera Prevotella, Megasphaera, Catenibacterium, Lactobacillus, Ruminococcus and species Prevotella copri, Lactobacillus ruminis as the potential biomarkers of diet.en_US
dc.format.extent12 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAMB Expressen_US
dc.rights© 2018 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
dc.subjectNext-generation Sequencingen_US
dc.subjectGut Microbiotaen_US
dc.subjectDRNTU::Engineering::Chemical engineeringen_US
dc.titleSimilarities and differences in gut microbiome composition correlate with dietary patterns of Indian and Chinese adultsen_US
dc.typeJournal Article
dc.contributor.researchNanyang Environment and Water Research Instituteen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.identifier.doihttp://dx.doi.org/10.1186/s13568-018-0632-1
dc.description.versionPublished versionen_US


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