dc.contributor.authorHuang, Shuo
dc.contributor.authorWei, Xin
dc.contributor.authorWang, Mingfeng
dc.identifier.citationHuang, S., Wei, X., & Wang, M. (2018). Self-assembled nanostructures of red fluorescent amphiphilic block copolymers as both imaging probes and drug carriers. Polymers, 10(10), 1120-. doi:10.3390/polym10101120en_US
dc.description.abstractWe report a red-fluorescent drug delivery system formed by biodegradable and biocompatible amphiphilic A-B-A block copolymers. Each polymer consists of a red fluorescent dye covalently bonded in the middle of hydrophobic block (B) of polylactone, tethered at both ends with poly[(oligo ethylene glycol) methyl ether methacrylate] (POEGMA) as the hydrophilic block. Two types of polylactones, i.e., semicrystalline poly(ε-caprolactone) (PCL) and amorphous poly(δ-decalactone) (PDL), respectively, were incorporated as the hydrophobic segment in the block copolymers. Using transmission electron microscopy, we characterized the self-assembled nanostructures formed by these amphiphilic block copolymers in mixtures of water/tetrahydrofuran or water/dimethylformamide. All of these polymers remained highly fluorescent in water, although some extent of aggregation-induced fluorescence quenching was still observed. Among the three types of polymers presented here, the polymer (RPO-3) containing an amorphous block of PDL showed the highest drug-loading capacity and the largest extent of drug release in acidic media. RPO-3 micelles loaded with doxorubicin as a model of anticancer drug showed sustainable intracellular release and cytotoxicity against HeLa cells.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent13 p.en_US
dc.rights© 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectDRNTU::Engineering::Chemical engineering::Biochemical engineeringen_US
dc.titleSelf-assembled nanostructures of red fluorescent amphiphilic block copolymers as both imaging probes and drug carriersen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionPublished versionen_US

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