dc.contributor.authorLiang, Shaohong
dc.contributor.authorHapuarachchi, Hapuarachchige Chanditha
dc.contributor.authorRajarethinam, Jayanthi
dc.contributor.authorKoo, Carmen
dc.contributor.authorTang, Choon-Siang
dc.contributor.authorChong, Chee-Seng
dc.contributor.authorNg, Lee-Ching
dc.contributor.authorYap, Grace
dc.identifier.citationLiang, S., Hapuarachchi, H. C., Rajarethinam, J., Koo, C., Tang, C.-S., Chong, C.-S., ... Yap, G. (2018). Construction sites as an important driver of dengue transmission: implications for disease control. BMC Infectious Diseases, 18(1), 382-. doi:10.1186/s12879-018-3311-6en_US
dc.description.abstractBackground:In 2013 and 2014, Singapore experienced its worst dengue outbreak known-to-date. Mosquito breeding in construction sites stood out as a probable risk factor due to its association with major dengue clusters in both years. We, therefore, investigated the contribution of construction sites to dengue transmission in Singapore, highlighting three case studies of large construction site-associated dengue clusters recorded during 2013–16.Methods:The study included two components; a statistical analysis of cluster records from 2013 to 2016, and case studies of three biggest construction site-associated clusters. We explored the odds of construction site-associated clusters growing into major clusters and determined whether clusters seeded in construction sites demonstrated a higher tendency to expand into major clusters. DENV strains obtained from dengue patients residing in three major clusters were genotyped to determine whether the same strains expanded into the surroundings of construction sites.Results:Despite less than 5% of total recorded clusters being construction site-associated, the odds of such clusters expanding into major clusters were 17.4 (2013), 9.2 (2014), 3.3 (2015) and 4.3 (2016) times higher than non-construction site clusters. Aedes premise index and average larvae count per habitat were also higher in construction sites than residential premises during the study period. The majority of cases in clusters associated with construction sites were residents living in the surroundings. Virus genotype data from three case study sites revealed a transmission link between the construction sites and the surrounding residential areas. Conclusions:Significantly high case burden and the probability of cluster expansion due to virus spill-over into surrounding areas suggested that construction sites play an important role as a driver of sustained dengue transmission. Our results emphasise that the management of construction-site associated dengue clusters should not be limited to the implicated construction sites, but be extended to the surrounding premises to prevent further transmission.en_US
dc.format.extent10 p.en_US
dc.relation.ispartofseriesBMC Infectious Diseasesen_US
dc.rights© 2018 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.subjectEnvironmental Driveren_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleConstruction sites as an important driver of dengue transmission: implications for disease controlen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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