From conventional to unconventional : glycosylation on semi-protected donors and syntheses towards natural products
Date of Issue2018-12-31
School of Physical and Mathematical Sciences
The specific stereo-configuration at each anomeric linkage and the diversity in branching burdens the synthesis of glycans. In this thesis, we introduce a widely applicable open-glycosylation method for the boron-assisted construction of various glycosidic connections. Furthermore, we manifested the practicality of this approach in a one-pot assembly of a model trisaccharide. Lastly, we conceptualized a divergent synthetic route for the syntheses of natural products and made significant steps towards their completion.