dc.contributor.authorLu, Shengtao
dc.contributor.authorBi, Wuguo
dc.contributor.authorDu, Quanchao
dc.contributor.authorSinha, Sheetal
dc.contributor.authorWu, Xiangyang
dc.contributor.authorSubrata, Arnold
dc.contributor.authorBhattacharjya, Surajit
dc.contributor.authorXing, Bengang
dc.contributor.authorYeow, Edwin Kok Lee
dc.identifier.citationLu, S., Bi, W., Du, Q., Sinha, S., Wu, X., Subrata, A., . . . Yeow, E. K. L. (2018). Lipopolysaccharide-affinity copolymer senses the rapid motility of swarmer bacteria to trigger antimicrobial drug release. Nature Communications, 9(1), 4277-. doi:10.1038/s41467-018-06729-6en_US
dc.description.abstractAn intelligent drug release system that is triggered into action upon sensing the motion of swarmer P. mirabilis is introduced. The rational design of the drug release system focuses on a pNIPAAm-co-pAEMA copolymer that prevents drug leakage in a tobramycin-loaded mesoporous silica particle by covering its surface via electrostatic attraction. The copolymer chains are also conjugated to peptide ligands YVLWKRKRKFCFI-NH2 that display affinity to Gram-negative bacteria. When swarmer P. mirabilis cells approach and come in contact with the particle, the copolymer-YVLWKRKRKFCFI-NH2 binds to the lipopolysaccharides on the outer membrane of motile P. mirabilis and are stripped off the particle surface when the cells move away; hence releasing tobramycin into the swarmer colony and inhibiting its expansion. The release mechanism is termed Motion-Induced Mechanical Stripping (MIMS). For swarmer B. subtilis, the removal of copolymers from particle surfaces via MIMS is not apparent due to poor adherence between bacteria and copolymer-YVLWKRKRKFCFI-NH2 system.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent10 p.en_US
dc.relation.ispartofseriesNature Communicationsen_US
dc.rights© 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectSwarmer Bacteriaen_US
dc.subjectDrug Releaseen_US
dc.titleLipopolysaccharide-affinity copolymer senses the rapid motility of swarmer bacteria to trigger antimicrobial drug releaseen_US
dc.typeJournal Article
dc.contributor.researchNanyang Environment and Water Research Instituteen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.versionPublished versionen_US
dc.contributor.organizationAdvanced Environmental Biotechnology Centreen_US

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