dc.contributor.authorThanawalla, Ayesha Rustom
dc.identifier.citationThanawalla, A. R. (2018). Control of skilled movement by the cerebellar interposed anterior nucleus. Doctoral thesis, Nanyang Technological University, Singapore.
dc.description.abstractAs the output channels of the cerebellum, the deep cerebellar nuclei (DCN) represent an important element of cerebellar circuits for control of voluntary movements. In this study, we address the role of neurons in the DCN using the Ucn3::Cre mouse which drives recombination in the interposed anterior nucleus (IntA). Manipulation of IntA neurons resulted in deficits in the kinematic parameters of limb movement during skilled reaching and locomotion. Furthermore, IntA neurons were also found to reduce activity in extensor muscle synergies. Finally, we present anatomical evidence that suggests neurons in the IntA nucleus may influence movement through cerebello-thalamo-cortical and/or rubrospinal pathways. Together, we identified a novel genetic tool for the interrogation of the connectivity and function of the IntA nucleus and defined the functional significance of a subpopulation of neurons in the IntA nucleus.en_US
dc.format.extent109 p.en_US
dc.subjectDRNTU::Science::Biological sciences::Molecular biologyen_US
dc.titleControl of skilled movement by the cerebellar interposed anterior nucleusen_US
dc.contributor.researchNTU-Warwick Neuroscience Programen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorAlbert I. Chenen_US
dc.description.degreeDoctor of Philosophyen_US

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