dc.contributor.authorXu, Weili
dc.date.accessioned2019-02-04T03:25:17Z
dc.date.available2019-02-04T03:25:17Z
dc.date.issued2019-02-04
dc.identifier.citationXu, W. (2019). The Immunosenescence of αβ & γδ T cells in human blood and skin. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10220/47613
dc.description.abstractStudies in human aging mainly focus on αβ T cells while γδ T cells and skin-resident T cells have been neglected despite their role in immunosurveillance. In this thesis, we showed that peripheral Vδ2+ are differentially susceptible to life-long stresses as compared to other αβ and γδ T cells. Using aging, cytomegalovirus history as immunological models and via the different functional assays, we show that Vδ2+ T cells are protected from cellular senescence. Next, we also investigated the skin-resident T cells and show that they are also differentially susceptible to life-long stresses as compared to periphery T cells. In conclusion, this shows that not all immune cells in the host undergo similar process of immunosenescence and the underlying biology and mechanisms behind Vδ2+ and skin-resident T cells’ protection from cellular senescence with age could be exploited as possible interventions to other cell types or by itself to mitigate the “grey tsunami”.en_US
dc.format.extent176 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleThe Immunosenescence of αβ & γδ T cells in human blood and skinen_US
dc.typeThesis
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorAnis Larbien_US
dc.description.degreeDoctor of Philosophyen_US
dc.identifier.doihttps://doi.org/10.32657/10220/47613
dc.contributor.organizationA*STAR Singapore Immunology Networken_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record