dc.contributor.authorThan, Aung
dc.contributor.authorLiu, Chenghao
dc.contributor.authorChang, Hao
dc.contributor.authorDuong, Phan Khanh
dc.contributor.authorCheung, Gemmy Chui Ming
dc.contributor.authorXu, Chenjie
dc.contributor.authorWang, Xiaomeng
dc.contributor.authorChen, Peng
dc.date.accessioned2019-02-15T02:26:55Z
dc.date.available2019-02-15T02:26:55Z
dc.date.issued2018
dc.identifier.citationThan, A., Liu, C., Chang, H., Duong, P. K., Cheung, G. C. M., Xu, C., . . . Chen, P. (2018). Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nature Communications, 9(1), 4433-. doi:10.1038/s41467-018-06981-wen_US
dc.identifier.urihttp://hdl.handle.net/10220/47673
dc.description.abstractEye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye patch equipped with an array of detachable microneedles. These microneedles can penetrate the ocular surface tissue, and serve as implanted micro-reservoirs for controlled drug delivery. The biphasic drug release kinetics enabled by the double-layered micro-reservoirs largely enhances therapeutic efficacy. Using corneal neovascularization as the disease model, we show that delivery of an anti-angiogenic monoclonal antibody (DC101) by such eye patch produces ~90% reduction of neovascular area. Furthermore, quick release of an anti-inflammatory compound (diclofenac) followed by a sustained release of DC101 provides synergistic therapeutic outcome. The eye patch application is easy and minimally invasive to ensure good patient compliance. Such intraocular drug delivery strategy promises effective home-based treatment of many eye diseases.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent12 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesNature Communicationsen_US
dc.rights© 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectDRNTU::Engineering::Chemical engineeringen_US
dc.subjectDC101en_US
dc.subjectMicroneedlesen_US
dc.titleSelf-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug deliveryen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doihttp://dx.doi.org/10.1038/s41467-018-06981-w
dc.description.versionPublished versionen_US


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