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Title: Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes
Authors: Chen, Qiao
Zhu, Tingshun
Majhi, Pankaj Kumar
Mou, Chengli
Chai, Huifang
Zhang, Jingjie
Zhuo, Shitian
Chi, Robin Yonggui
Keywords: DRNTU::Science::Chemistry
N-heterocyclic Carbene
Issue Date: 2018
Source: Chen, Q., Zhu, T., Majhi, P. K., Mou, C., Chai, H., Zhang, J., . . . Chi, Y. R. (2018). Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes. Chemical Science, 9(46), 8711-8715. doi:10.1039/C8SC03480J
Series/Report no.: Chemical Science
Abstract: Di(hetero)arylmethane is a unique structural motif for natural and synthetic functional molecules. To date, it remains challenging to functionalize the diaryl methyl sp3 carbon–hydrogen bond directly in an enantioselective manner. This is likely due to the relatively inert nature of the carbon–hydrogen bond and the difficult enantiofacial discrimination of two sterically similar aryl substituents. Here we disclose an N-heterocyclic carbene-catalyzed direct oxidative coupling of enals and di(hetero)arylmethanes. Our method allows for highly enantioselective transformation of diaryl methanes and quick access to benzimidazole fused lactams.
ISSN: 2041-6520
Rights: © 2018 The Author(s) (published by Royal Society of Chemistry). This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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