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Title: Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont
Authors: Longford, Sharon Rae
Steinberg, Peter David
Campbell, Alexandra H.
Nielsen, Shaun
Case, Rebecca J.
Kjelleberg, Staffan
Keywords: DRNTU::Science::Biological sciences
Applied Microbiology
Microbial Ecology
Issue Date: 2019
Source: Longford, S. R., Campbell, A. H., Nielsen, S., Case, R. J., Kjelleberg, S., & Steinberg, P. D. (2019). Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont. Scientific Reports, 9, 1363-. doi:10.1038/s41598-018-37062-z
Series/Report no.: Scientific Reports
Abstract: Our understanding of diseases has been transformed by the realisation that people are holobionts, comprised of a host and its associated microbiome(s). Disease can also have devastating effects on populations of marine organisms, including dominant habitat formers such as seaweed holobionts. However, we know very little about how interactions between microorganisms within microbiomes - of humans or marine organisms – affect host health and there is no underpinning theoretical framework for exploring this. We applied ecological models of succession to bacterial communities to understand how interactions within a seaweed microbiome affect the host. We observed succession of surface microbiomes on the red seaweed Delisea pulchra in situ, following a disturbance, with communities ‘recovering’ to resemble undisturbed states after only 12 days. Further, if this recovery was perturbed, a bleaching disease previously described for this seaweed developed. Early successional strains of bacteria protected the host from colonisation by a pathogenic, later successional strain. Host chemical defences also prevented disease, such that within-microbiome interactions were most important when the host’s chemical defences were inhibited. This is the first experimental evidence that interactions within microbiomes have important implications for host health and disease in a dominant marine habitat-forming organism.
Rights: © 2019 The Author(s) (Nature Publishing Group). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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