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Title: Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease
Authors: Vinding, Mikkel C.
Tsitsi, Panagiota
Piitulainen, Harri
Waldthaler, Josefine
Jousmäki, Veikko
Ingvar, Martin
Svenningsson, Per
Lundqvist, Daniel
Keywords: DRNTU::Science::Medicine
Motor Cortex
Issue Date: 2019
Source: Vinding, M. C., Tsitsi, P., Piitulainen, H., Waldthaler, J., Jousmäki, V., Ingvar, M., . . . Lundqvist, D. (2019). Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease. Scientific Reports, 9, 2604-. doi:10.1038/s41598-019-39204-3
Series/Report no.: Scientific Reports
Abstract: Motor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8–30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical processing of proprioceptive afference in PD.
Rights: © 2019 The Author(s) (Nature Publishing Group). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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