dc.contributor.authorHuang, Xiaolei
dc.contributor.authorOh, William Ray Jun Jie
dc.contributor.authorZhou, Steve Jianrong
dc.date.accessioned2019-05-21T07:10:54Z
dc.date.available2019-05-21T07:10:54Z
dc.date.issued2018
dc.identifier.citationHuang, X., Oh, W. R. J. J., & Zhou, S. J. (2018). Palladium-Catalyzed Enantioselective Arylation of Racemic Ketones to Form Bridged Bicycles via Dynamic Kinetic Resolution. Angewandte Chemie International Edition, 57(26), 7673-7677. doi:10.1002/anie.201804318en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10220/48295
dc.description.abstractEnantioselective α‐arylation of racemic ketones containing existing α′‐stereocenters is reported for the first time via base‐induced dynamic kinetic resolution. Bridged bicyclic rings are formed in good ee values, which are difficult to obtain otherwise. Furthermore, reactions in DMSO‐d6 resulted in extensive deuteration of both α‐ and α′‐positions in the products, thus supporting a pathway involving rapid, reversible deprotonation of ketones under catalytic conditions.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent5 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAngewandte Chemie International Editionen_US
dc.rights© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Huang, X., Oh, W. R. J. J., & Zhou, S. J. (2018). Palladium-Catalyzed Enantioselective Arylation of Racemic Ketones to Form Bridged Bicycles via Dynamic Kinetic Resolution. Angewandte Chemie International Edition, 57(26), 7673-7677, which has been published in final form at http://dx.doi.org/10.1002/anie.201804318. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectPalladium Catalysisen_US
dc.subjectAlkylationen_US
dc.subjectDRNTU::Science::Chemistryen_US
dc.titlePalladium-catalyzed enantioselective arylation of racemic ketones to form bridged bicycles via dynamic kinetic resolutionen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201804318
dc.description.versionAccepted versionen_US


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