Palladium-catalyzed para-selective alkylation of electron-deficient arenes
Lim, Li Hui
Zhou, Steve Jianrong
Date of Issue2018
School of Physical and Mathematical Sciences
Intermolecular alkylations of electron‐deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical Friedel–Crafts alkylations, which prefer electron‐rich systems.
Angewandte Chemie International Edition
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Jiao, Z., Lim, L. H., Hirao, H., & Zhou, S. J. (2018). Palladium-catalyzed para-selective alkylation of electron-deficient arenes. Angewandte Chemie International Edition, 57(21), 6294-6298, which has been published in final form at http://dx.doi.org/10.1002/anie.201801967. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.