Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82606
Title: Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury
Authors: Huang, Jiaguo
Li, Jingchao
Lyu, Yan
Miao, Qingqing
Pu, Kanyi
Keywords: Diagnostics
DRNTU::Engineering::Chemical engineering
Fluorescent Probes
Issue Date: 2019
Source: Huang, J., Li, J., Lyu, Y., Miao, Q., & Pu, K. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nature Materials. doi:10.1038/s41563-019-0378-4
Series/Report no.: Nature Materials
Abstract: Drug-induced acute kidney injury (AKI) with a high morbidity and mortality is poorly diagnosed in hospitals and deficiently evaluated in drug discovery. Here, we report the development of molecular renal probes (MRPs) with high renal clearance efficiency for in vivo optical imaging of drug-induced AKI. MRPs specifically activate their near-infrared fluorescence or chemiluminescence signals towards the prodromal biomarkers of AKI including the superoxide anion, N-acetyl-β-D-glucosaminidase and caspase-3, enabling an example of longitudinal imaging of multiple molecular events in the kidneys of living mice. Importantly, they in situ report the sequential occurrence of oxidative stress, lysosomal damage and cellular apoptosis, which precedes clinical manifestation of AKI (decreased glomerular filtration). Such an active imaging mechanism allows MRPs to non-invasively detect the onset of cisplatin-induced AKI at least 36 h earlier than the existing imaging methods. MRPs can also act as exogenous tracers for optical urinalysis that outperforms typical clinical/preclinical assays, demonstrating their clinical promise for early diagnosis of AKI.
URI: https://hdl.handle.net/10356/82606
http://hdl.handle.net/10220/48884
ISSN: 1476-1122
DOI: 10.1038/s41563-019-0378-4
Rights: © 2019 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This paper was published in Nature Materials and is made available with permission of Macmillan Publishers Limited, part of Springer Nature.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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