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https://hdl.handle.net/10356/106247
Title: | Dissolvable polyvinyl-alcohol film, a time-barrier to modulate sample flow in a 3d-printed holder for capillary flow paper diagnostics | Authors: | Yitian, Alicia Lu Eltzov, Evgeni Marks, Robert S. Tok, Alfred Iing Yoong Harpaz, Dorin Axelrod, Tim |
Keywords: | DRNTU::Engineering::Materials Polyvinyl Alcohol Dissolvable Membrane |
Issue Date: | 2019 | Source: | Harpaz, D., Axelrod, T., Yitian, A. L., Eltzov, E., Marks, R. S., & Tok, A. I. Y. (2019). Dissolvable Polyvinyl-Alcohol Film, a Time-Barrier to Modulate Sample Flow in a 3D-Printed Holder for Capillary Flow Paper Diagnostics. Materials, 12(3), 343-. doi:10.3390/ma12030343 | Series/Report no.: | Materials | Abstract: | Integrating a dissolvable membrane into a sensor allows the control of sample flow, location and duration in critical areas. These time-barrier films stop the flow of samples until the membrane has dissolved, thus, for example, allowing increased exposure time between immunoreagents for the formation of greater numbers of immuno-complexes, ensuring higher sensitivity, reactivity, and helping to reduce false-positive signals. In this study, dissolvable polyvinyl alcohol (PVA) films are used in a 3D-printed sensor holder, which enables film integration without the use of glue. PVA is a synthetic hydrophilic linear polymer, its solubility is dependent on its molecular weight and degree of hydrolysis. Three types of PVAs films were tested herein: (1) PVA 1-Mw: 30–70 K, 87–90% hydrolyzed; (2) PVA 2-Mw: 31–50 K, 98–99% hydrolyzed and (3) PVA 3-Mw: 89–98 K, >99% hydrolyzed. The films were exposed to water in (1) the novel 3D-printed holder and (2) directly immersed into a water droplet. After comparing the time taken to dissolve PVA 1–3 films, PVA 1 films of 5–20% (w/v) are found to be most suitable as time barrier films, due to their optimal dissolution times and physical properties for integration into the customized 3D-printed holder. | URI: | https://hdl.handle.net/10356/106247 http://hdl.handle.net/10220/48914 |
ISSN: | 1996-1944 | DOI: | 10.3390/ma12030343 | Schools: | School of Materials Science & Engineering | Organisations: | Institute for Sports Research | Rights: | © 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MSE Journal Articles |
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Dissolvable Polyvinyl-Alcohol Film, a Time-Barrier to.pdf | 3.51 MB | Adobe PDF | View/Open |
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