dc.contributor.authorRamalingam, Raghavendra
dc.contributor.authorDhand, Chetna
dc.contributor.authorLeung, Chak Ming
dc.contributor.authorEzhilarasu, Hariharan
dc.contributor.authorPrasannan, Praseetha
dc.contributor.authorOng, Seow Theng
dc.contributor.authorSubramanian, Sundarapandian
dc.contributor.authorMohammed Kamruddin
dc.contributor.authorLakshminarayanan, Rajamani
dc.contributor.authorRamakrishna, Seeram
dc.contributor.authorVerma, Navin Kumar
dc.contributor.authorArunachalam, Kantha Deivi
dc.identifier.citationRamalingam, R., Dhand, C., Leung, C. M., Ezhilarasu, H., Prasannan, P., Ong, S. T., . . . Arunachalam, K. D. (2019). Poly-ε-caprolactone/gelatin hybrid electrospun composite nanofibrous mats containing ultrasound assisted herbal extract : antimicrobial and cell proliferation study. Nanomaterials, 9(3), 462-. doi:10.3390/nano9030462en_US
dc.description.abstractElectrospun fibers have emerged as promising materials in the field of biomedicine, due to their superior physical and cell supportive properties. In particular, electrospun mats are being developed for advanced wound dressing applications. Such applications require the firers to possess excellent antimicrobial properties in order to inhibit potential microbial colonization from resident and non-resident bacteria. In this study, we have developed Poly-ε-Caprolactone /gelatin hybrid composite mats loaded with natural herbal extract (Gymnema sylvestre) to prevent bacterial colonization. As-spun scaffolds exhibited good wettability and desirable mechanical properties retaining their fibrous structure after immersing them in phosphate buffered saline (pH 7.2) for up to 30 days. The initial burst release of Gymnema sylvestre prevented the colonization of bacteria as confirmed by the radial disc diffusion assay. Furthermore, the electrospun mats promoted cellular attachment, spreading and proliferation of human primary dermal fibroblasts and cultured keratinocytes, which are crucial parenchymal cell-types involved in the skin recovery process. Overall these results demonstrated the utility of Gymnema sylvestre impregnated electrospun PCL/Gelatin nanofibrous mats as an effective antimicrobial wound dressing.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.description.sponsorshipMOH (Min. of Health, S’pore)en_US
dc.format.extent21 p.en_US
dc.rights© 2019 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectElectrospun Hybrid Matsen_US
dc.subjectUltrasound Assisted Extractionen_US
dc.titlePoly-ε-caprolactone/gelatin hybrid electrospun composite nanofibrous mats containing ultrasound assisted herbal extract : antimicrobial and cell proliferation studyen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.versionPublished versionen_US

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