Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82961
Title: A systematic review of gut‐immune‐brain mechanisms in Autism Spectrum Disorder
Authors: Azhari, Atiqah
Azizan, Farouq
Esposito, Gianluca
Keywords: Autism Spectrum Disorder
Immune System
Humanities::General::Education
Issue Date: 2019
Source: Azhari, A., Azizan, F., & Esposito, G. (2019). A systematic review of gut-immune-brain mechanisms in Autism Spectrum Disorder. Developmental Psychobiology, 61(5), 752-771. doi:10.1002/dev.21803
Series/Report no.: Developmental Psychobiology
Abstract: Despite decades of research, the etiological origins of Autism Spectrum Disorder (ASD) remain elusive. Recently, the mechanisms of ASD have encompassed emerging theories involving the gastrointestinal, immune, and nervous systems. While each of these perspectives presents its own set of supporting evidence, the field requires an integration of these modular concepts and an overarching view of how these subsystems intersect. In this systematic review, we have synthesized relevant evidences from the existing literature, evaluating them in an interdependent manner and in doing so, outlining their possible connections. Specifically, we first discussed gastrointestinal and immuno-inflammation pathways in-depth, exploring the relationships between microbial composition, bacterial metabolites, gut mucosa, and immune system constituents. Accounting for temporal differences in the mechanisms involved in neurodevelopment, prenatal and postnatal phases were further elucidated, where the former focused on maternal immune activation (MIA) and fetal development, while the latter addressed the role of immune dysregulation in contributing to atypical neurodevelopment. As autism remains, foremost, a neurodevelopmental disorder, this review presents an integration of disparate modules into a "Gut-Immune-Brain" paradigm. Existing gaps in the literature have been highlighted, and possible avenues for future research with an integrated physiological perspective underlying ASD have also been suggested.
URI: https://hdl.handle.net/10356/82961
http://hdl.handle.net/10220/49107
ISSN: 0012-1630
DOI: https://dx.doi.org/10.1002/dev.21803
Rights: This is the peer reviewed version of the following article: Azhari, A., Azizan, F., & Esposito, G. (2019). A systematic review of gut-immune-brain mechanisms in Autism Spectrum Disorder. Developmental Psychobiology, 61(5), 752-771. doi:10.1002/dev.21803, which has been published in final form at https://dx.doi.org/10.1002/dev.21803. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
metadata.item.grantfulltext: embargo_20210731
metadata.item.fulltext: With Fulltext
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