Please use this identifier to cite or link to this item:
Title: Crystal chemistry and antibacterial properties of cupriferous hydroxyapatite
Authors: Hooper, Thomas J. N.
Kelly, Nicole L.
Gupta, Disha
Balani, Kantesh
Manna, Indranil
Baikie, Tom
Bishop, Peter T.
White, Timothy J.
Hanna, John V.
Bhattacharjee, Arjak
Fang, Yanan
Keywords: Hydroxyapatite
Copper Doping
Issue Date: 2019
Source: Bhattacharjee, A., Fang, Y., Hooper, T. J. N., Kelly, N. L., Gupta, D., Balani, K., . . . Hanna, J. (2019). Crystal Chemistry and Antibacterial Properties of Cupriferous Hydroxyapatite. Materials, 12(11), 1814-. doi:10.3390/ma12111814
Series/Report no.: Materials
Abstract: Copper-doped hydroxyapatite (HA) of nominal composition Ca10(PO4)6[Cux(OH)2-2xOx] (0.0 ≤ x ≤ 0.8) was prepared by solid-state and wet chemical processing to explore the impact of the synthesis route and mode of crystal chemical incorporation of copper on the antibacterial efficacy against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) strains. Apatites prepared by solid-state reaction showed unit cell volume dilation from 527.17 Å3 for copper-free HA to 533.31 Å3 for material of the putative composition Ca10(PO4)6[Cu0.8(OH)0.4O0.8] consistent with Cu+ insertion into the [001] hydroxyapatite channel. This was less pronounced (528.30 Å3 to 529.3 Å3) in the corresponding wet chemical synthesised products, suggesting less complete Cu tunnel incorporation and partial tenancy of Cu in place of calcium. X-ray absorption spectroscopy suggests fast quenching is necessary to prevent oxidation of Cu+ to Cu2+. Raman spectroscopy revealed an absorption band at 630 cm−1 characteristic of symmetric O-Cu+-O units tenanted in the apatite channel while solid-state 31P magic-angle-spinning nuclear magnetic resonance (MAS NMR) supported a vacancy-Cu+ substitution model within the apatite channel. The copper doping strategy increases antibacterial efficiency by 25% to 55% compared to undoped HA, with the finer particle sizes and greater specific surface areas of the wet chemical material demonstrating superior efficacy.
ISSN: 1996-1944
DOI: 10.3390/ma12111814
Rights: © 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

Files in This Item:
File Description SizeFormat 
Crystal Chemistry and Antibacterial Properties of Cupriferous Hydroxyapatite.pdf5.27 MBAdobe PDFThumbnail

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.