View Item 
      •   Home
      • 1. Schools
      • College of Engineering
      • School of Chemical and Biomedical Engineering (SCBE)
      • SCBE Conference Papers
      • View Item
      •   Home
      • 1. Schools
      • College of Engineering
      • School of Chemical and Biomedical Engineering (SCBE)
      • SCBE Conference Papers
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.
      Subject Lookup

      Browse

      All of DR-NTUCommunities & CollectionsTitlesAuthorsBy DateSubjectsThis CollectionTitlesAuthorsBy DateSubjects

      My Account

      Login

      Statistics

      Most Popular ItemsStatistics by Country/RegionMost Popular Authors

      About DR-NTU

      A study of blood clots using photoacoustic imaging during sonothrombolysis

      Thumbnail
      SPIE 2019_PA imaging of a blood clot during sonothrombolysis.pdf (1013.Kb)
      Author
      Das, Dhiman
      Pramanik, Manojit
      Date of Issue
      2019
      Conference Name
      Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2019
      School
      School of Chemical and Biomedical Engineering
      Version
      Accepted version
      Abstract
      Formation of blood clots or thrombus in healthy blood vessels can lead to serious or even life-threatening complications. Sonothrombolysis is a promising tool for lysing the blood clots non-invasively using focused acoustic waves. Ultrasound (US) imaging is commonly used to detect the blood clots presents in veins. In this work, we explore the use of a combined ultrasound and photoacoustic (PA) imaging clinical system during sonothrombolysis. PA imaging is a hybrid and emerging imaging modality which has garnered the attention of the biomedical imaging community in recent years. While US imaging has been used to visualize the blood clot, PA imaging enables the study of composition of the blood clot due to its optical absorption. Blood clots may be red, white or mixed due to the higher count of red blood cells (RBCs), white blood cells (WBCs) or it being a combination of RBCs and WBCs, respectively. Each clot type has a different photoacoustic signal. In our work, blood clots rich in RBCs are taken in transparent polyurethane tubes for sonothrombolysis. Meanwhile, the ultrasound and photoacoustic signal-to-noise ratios (SNR) are measured at fixed time intervals to evaluate the size and optical properties of the clot. Two cases were taken: blood clot + DI water and blood clot + blood and their US and PA SNR values were compared after 30 mins of sonothrombolysis treatment. The PA signal of the blood clot obtained after performing sonothrombolysis can be used to determine its final composition which may, in turn, help in the administration of clot-dissolving drugs.
      Subject
      Blood Clot
      Sonothrombolysis
      Engineering::Chemical engineering
      Type
      Conference Paper
      Rights
      © 2019 Society of Photo-optical Instrumentation Engineers (SPIE). All rights reserved. This paper was published in Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2019 and is made available with permission of Society of Photo-optical Instrumentation Engineers (SPIE).
      Collections
      • SCBE Conference Papers
      https://dx.doi.org/10.1117/12.2508374
      Get published version (via Digital Object Identifier)

      Show full item record


      NTU Library, Nanyang Avenue, Singapore 639798 © 2011 Nanyang Technological University. All rights reserved.
      DSpace software copyright © 2002-2015  DuraSpace
      Contact Us | Send Feedback
      Share |    
      Theme by 
      Atmire NV
       

       


      NTU Library, Nanyang Avenue, Singapore 639798 © 2011 Nanyang Technological University. All rights reserved.
      DSpace software copyright © 2002-2015  DuraSpace
      Contact Us | Send Feedback
      Share |    
      Theme by 
      Atmire NV
       

       

      DCSIMG