dc.contributor.authorMansoor, Hassan
dc.contributor.authorOng, Hon Shing
dc.contributor.authorRiau, Andri K.
dc.contributor.authorStanzel, Tisha P.
dc.contributor.authorMehta, Jodhbir Singh
dc.contributor.authorYam, Gary Hin-Fai
dc.date.accessioned2019-08-22T05:39:06Z
dc.date.available2019-08-22T05:39:06Z
dc.date.issued2019
dc.identifier.citationMansoor, H., Ong, H. S., Riau, A. K., Stanzel, T. P., Mehta, J. S., & Yam, G. H.-F. (2019). Current Trends and Future Perspective of Mesenchymal Stem Cells and Exosomes in Corneal Diseases. International Journal of Molecular Sciences, 20(12), 2853-. doi:10.3390/ijms20122853en_US
dc.identifier.issn1661-6596en_US
dc.identifier.urihttp://hdl.handle.net/10220/49747
dc.description.abstractThe corneal functions (transparency, refractivity and mechanical strength) deteriorate in many corneal diseases but can be restored after corneal transplantation (penetrating and lamellar keratoplasties). However, the global shortage of transplantable donor corneas remains significant and patients are subject to life-long risk of immune response and graft rejection. Various studies have shown the differentiation of multipotent mesenchymal stem cells (MSCs) into various corneal cell types. With the unique properties of immunomodulation, anti-angiogenesis and anti-inflammation, they offer the advantages in corneal reconstruction. These effects are widely mediated by MSC differentiation and paracrine signaling via exosomes. Besides the cell-free nature of exosomes in circumventing the problems of cell-fate control and tumorigenesis, the vesicle content can be genetically modified for optimal therapeutic affinity. The pharmacology and toxicology, xeno-free processing with sustained delivery, scale-up production in compliant to Good Manufacturing Practice regulations, and cost-effectiveness are the current foci of research. Routes of administration via injection, topical and/or engineered bioscaffolds are also explored for its applicability in treating corneal diseases.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.format.extent28 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen_US
dc.rights© 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectExosomesen_US
dc.subjectEngineering::Materialsen_US
dc.titleCurrent trends and future perspective of mesenchymal stem cells and exosomes in corneal diseasesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.3390/ijms20122853
dc.description.versionPublished versionen_US


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