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Title: Spinal cord organoids add an extra dimension to traditional motor neuron cultures
Authors: Winanto
Khong, Zi-Jian
Hor, Jin-Hui
Ng, Shi-Yan
Keywords: Spinal Cord
Amyotrophic Lateral Sclerosis
Science::Biological sciences
Issue Date: 2019
Source: Winanto., Khong, Z.-J., Hor, J.-H., & Ng, S.-Y. (2019). Spinal cord organoids add an extra dimension to traditional motor neuron cultures. Neural Regeneration Research, 14(9), 1515-. doi:10.4103/1673-5374.255966
Series/Report no.: Neural Regeneration Research
Abstract: Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural organoids are 3D cell culture systems formed by proliferating, differentiating, migrating and self-organizing pools of neural progenitors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013).
ISSN: 1673-5374
DOI: 10.4103/1673-5374.255966
Rights: © 2019 Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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